PCOS or polycystic ovary syndrome is a complex disorder or rather a spectral disorder with no uniform clinic or laboratory diagnostic criteria. PCOS is one of the most common hormonal disturbances affecting women all over the world . It has an unknown etiology, and is recognized as a heterogeneous disorder that results in overproduction of the male hormone, primarily from the ovary. It is also associated with insulin resistance .
The journey, the struggles and the treatment approach for each patient is different. As contrary to the popular belief , the manifestations are more severe in obese individuals with PCOS, but there is another phenotype known as lean pcos. Those women who have pcos can be sub- grouped, based on clinical features that are suggestive of endocrinological malfunction, and can be investigated accordingly for selection of appropriate treatment modalities.
The cornerstone to PCOS pathology is insulin resistance, which means that the body doesn’t respond normally to insulin, thereby increasing insulin secretion from pancreas. This triggers inflammation and weight gain. High insulin levels are both a diagnostic criteria, and also the underlying physiological driver. High insulin causes anovulation and also promotes testosterone secretion from ovaries( hyperandrogenism) . The skin features in PCOS, sometimes present earlier, can help in early detection and prevention of disease progression.
1. Acanthosis nigricans is a skin disorder characterised by darkening and thickening of the skin, occurring mainly in the folds of the skin in the armpit (axilla), groin and back of the neck. Often treated as dirt , this condition is synonymous with insulin resistance and obesity. Sometimes it can be drug and malignancy induced too. The treatment approach is weight reduction and decreasing the insulin resistance with low glycemic diet and regular workouts. Skin lightening agents like retinoids , glycolic acid and treatments like tca peels also play a role in cosmetic improvement.
2. Hirsutism or unwanted facial hair is a result of hyperandrogenism or excess male hormone secretion. It mostly affects the chin, sidelocks, chest, thighs and even the nipple area . Treatment needs weight reduction to control the serum sex hormone binding globulin (SHBG) ,which In turn controls the free testosterone levels, androgen-lowering medication like spironolactone, OCPs and laser hair reduction
3. Females with persistent acne since teens or with acne presenting for the first time after 25 must be evaluated for PCOS . Acne in PCOS is generally resistant to standard acne treatments, and affects mainly the lower one third of the face. It is associated with extremely tender eruptions, suggesting more inflammation and shows premenstrual flare.
Treatment results take longer to respond, at least three months, and the best approach is to add combined oral contraceptives with anti-androgen progesterone like drospirenone and cyproterone acetate as well as spironolactone to control the hyperandrogenic state.
The role of supplements like inositol, magnesium, zinc and vitamin D play an important role in controlling the inflammatory state.
4. Seborrhoeic dermatitis often presents itself as oily scalp and dandruff. In severe cases, it can affect the oily areas of the skin like around the nose, between eyebrows and behind ears. Associated with more androgens and hence more oil secretion, it promotes the growth of a fungus called malassezia that needs treatment and daily cleansing of the scalp with a salicylic acid or ketoconazole shampoo .
5. Female patterned hair loss or hair thinning presenting mainly in the crown and frontal area is often ignored, until a major portion of the scalp becomes visible. Frequent changing of hairstyles to cover it up without seeking medical treatments leads to progression and greater damage. Starting minoxidil as a preventive therapy and doing platelet-rich plasma sessions may be helpful. PCOS is a disorder which affects the body not only at a hormonal level, thereby affecting metabolism and fertility, but it also has far-reaching effects on a person’s confidence when it has negative influence on appearance