A team of Michigan State University researchers found that poor sense of smell may signify a higher risk of pneumonia in older adults. An acute loss of smell is one of the most common symptoms of COVID-19, but for two decades it has been linked to other maladies like Parkinson’s disease and dementia.
The study was published in the journal Lancet Healthy Longevity. “About a quarter of adults 65 years or older have a poor sense of smell,” said Honglei Chen, a professor in the Department of Epidemiology and Biostatistics within MSU’s College of Human Medicine.
“Unlike vision or hearing impairment, this sensory deficit has been largely neglected; more than two-thirds of people with a poor sense of smell do not know they have it,” added Chen.
In a first-of-its-kind study, Chen and his team found a possible link between a poor sense of smell and a higher risk of pneumonia hospitalisation. They analysed 13 years of health data from 2,494 older adults, ages 71-82, from metropolitan areas of Pittsburgh, Pennsylvania, and Memphis, Tennessee.
This study aimed to examine whether a poor sense of smell in older adults is associated with a higher future risk of developing pneumonia.
The participants were given a Brief Smell Identification Test, or B-SIT, using common smells such as lemons and gasoline to determine if their sense of smell was good, moderate, or poor. Then, the participants were monitored for the next 13 years using clinical exams and follow-up phone calls to identify hospitalisation due to pneumonia.
The researchers found that compared with participants who had a good sense of smell, participants with a poor sense of smell were about 50 per cent more likely to be hospitalised with pneumonia at any time point during the 13-year follow-up. Among participants (with a poor sense of smell) who never had had pneumonia before, the risk of having first-ever pneumonia was about 40 per cent higher.
“To our knowledge, this study provides the first epidemiological evidence that poor olfaction (sense of smell) is associated with a long-term higher risk of pneumonia in older adults,” said Yaqun Yuan, a postdoctoral fellow in Chen’s research group.
This study provides novel evidence that a poor sense of smell may have broader health implications beyond its connections to Parkinson’s disease and dementia.
“This is just an example of how little we know about this common sensory deficit. Either as a risk factor or as a marker, poor sense of smell in older adults may herald multiple chronic diseases beyond what we have known about. We need to think out of the box,” Chen concluded.