Regular consumption of vitamin D can decrease the severity of Covid-19: Study

According to this PLoS study, understanding the ability of vitamin D to protect against severe Covid-19 illness can be a great boon for public health.
vitamin d and covid
Include vitamin D in your diet to beat Covid-19 blues. Image courtesy: Shutterstock
ANI Published: 2 Jun 2021, 10:42 am IST
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Observational studies have suggested that increased vitamin D levels may protect against COVID-19. However, these studies were inconclusive and possibly subject to confounding.

A study published in PLOS Medicine by Guillaume Butler-Laporte and Tomoko Nakanishi at McGill University in Quebec, Canada, and colleagues suggests that genetic evidence does not support vitamin D as a protective measure against COVID-19.

Here’s what the study has to say

The ability of vitamin D to protect against severe COVID-19 illness is of great interest to public health experts but has limited supporting evidence. To assess the relationship between vitamin D levels and COVID-19 susceptibility and severity, researchers conducted a Mendelian randomization study using genetic variants strongly associated with increased vitamin D levels.

vitamin d and covid-19
Vitamins are the way to battle covid-19, if this study is to be believed. Image courtesy: Shutterstock

The authors analyzed genetic variants of 4,134 individuals with COVID-19, and 1,284,876 without COVID-19, from 11 countries to determine whether genetic predisposition for higher vitamin D levels was associated with less-severe disease outcomes in people with COVID-19.

The results showed no evidence for an association between genetically predicted vitamin D levels and COVID-19 susceptibility, hospitalization, or severe disease, suggesting that raising circulating vitamin D levels through supplementation may not improve COVID-19 outcomes in the general population.

Go for natural sources of vitamin D

However, the study had several important limitations, including that the research did not include individuals with vitamin D deficiency, and it remains possible that truly deficient patients may benefit from supplementation for COVID-19 related protection and outcomes.

Additionally, the genetic variants were obtained only from individuals of European ancestry, so future studies will be needed to determine the relationship with COVID-19 outcomes in other populations.

According to the authors, “Vitamin D supplementation as a public health measure to improve outcomes is not supported by this study. Most importantly, our results suggest that investment in other therapeutic or preventative avenues should be prioritized for COVID-19 randomized clinical trials.”

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vitamin d and covid-19
Don’t underestimate the importance of vitamin D. Image courtesy: Shutterstock

Dr Butler-Laporte told that most vitamin D studies are very difficult to interpret since they cannot adjust for the known risk factors for severe Covid-19 (e.g. older age, institutionalization, having chronic diseases) which are also predictors of low vitamin D.

Therefore, the best way to answer the question of the effect of vitamin D would be through randomized trials, but these are complex and resource-intensive, and take a long time during a pandemic. Mendelian randomization can provide more clear insights into the role of risk factors like vitamin D because they can decrease potential bias from associated risk factors like institutionalization and chronic disease.

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In the past Mendelian randomization has consistently predicted results of large, expensive, and timely vitamin D trials. Here, this method does not show clear evidence that vitamin D supplementation would have a large effect on Covid-19 outcomes.

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