The Covid-19 pandemic has impacted life as we know it, leaving a lasting mark on our physical health and well-being. While most of the focus has been on the virus itself, recent findings suggest that the pandemic has also had a significant impact on our cognitive health, particularly in terms of Covid-19 brain ageing. The research involved analysing brain scans from 1,000 individuals. These scans were taken as the pandemic unfolded and were compared to those collected during “normal” times, serving as a benchmark for typical brain ageing.
A study published on July 22, 2025, in Nature Communications, offers compelling insights into how living through this unprecedented crisis has impacted the ageing of our brains—regardless of whether we contracted the virus.
One of the study’s most striking conclusions was that individuals who lived through the pandemic experienced accelerated brain ageing associated with Covid-19, with brain ageing approximately 5.5 months faster than that of those studied before the crisis. This accelerated ageing was evident regardless of Covid-19 infection status, indicating that factors unrelated to the virus—such as increased stress and altered daily routines—played a significant role.
The researchers assessed various measures, including:
Grey matter is required for functions such as memory, emotion regulation, and motor control, all of which can be impacted by Covid-19 brain ageing. White matter plays a vital role in transmitting signals between nerve cells.
“Initial brain imaging and earlier studies have demonstrated that patients who have contracted Covid-19, especially those experiencing moderate to severe conditions, have displayed less grey matter in regions involved in memory and emotional control. This trend resembles the first variations observed in a few neurodegenerative disorders,” explains Dr Neha Kapoor, Associate Director and Head-Neurology, Asian Hospital.
During the pandemic, many people experienced significant disruptions:
These factors collectively contributed to the acceleration of brain ageing, as evidenced by the study’s findings. The research emphasises that everyday life activities can influence brain health. Significant societal changes, such as those brought about by the Covid-19 pandemic, can have long-term implications for even healthy individuals, including effects like Covid-19 brain ageing.
“Not only severe Covid infection may provoke a robust inflammatory process in the brain, but mild Covid infection can also do so, causing damage to neural pathways and resulting in the loss of cognitive performance capacities, such as memory, attention, and decision-making”, shares Dr Kapoor.
The impact of the pandemic was not uniform. Specific demographics experienced more pronounced effects:
For instance, people with less stable employment showed an average of five additional months of brain ageing compared to those in stable jobs. Likewise, individuals in poorer health experienced an increase of approximately four months in brain age relative to their healthier counterparts, further complicating issues related to Covid-19 brain ageing as per the Science Media Centre.
Interestingly, only those infected with Covid-19 demonstrated a decline in cognitive skills. However, non-infected individuals also experienced signs of accelerated brain ageing, reaffirming the need to recognise the pandemic’s extensive effects on health beyond physical symptoms, according to the Science Media Centre.
While the study did not directly address specific interventions to combat brain ageing, it noted that certain lifestyle strategies are vital, especially in stressful times. Dr Kapoor emphasises the importance of incorporating cognitive screening and mental health care into post-covid care to prevent instances of such effects.
While these tips are known to support brain health, the study suggests that whether they can specifically reverse the changes observed during the pandemic, such as Covid-19 brain ageing, is still a matter for future research.
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